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pentobarbital raises toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may increase the metabolism of ifosfamide to its Lively alkylating metabolites.We report a scenario of survival adhering to deliberate self-poisoning that has a likely lethal dose of pentobarbital. In overdose,